Quote Originally Posted by panic_down_under View Post
Anafranil is a fairly strong antihistamine so will produce some sedation. This does diminish a little over time, but probably won't completely go away. The TCA I take is still sedating after nearly 21 years, although admittedly I am on a very high dose and it is a more potent antihistamine than Anafranil.

It is still early days so you may yet experience some other side-effects. They are usually milder than those from SSRIs, however, as with everything about antidepressants, YMMV.

When taken for more than a week Anafranil plasma levels stabilize to a steady-state and then don't vary much across 24 hours so it probably won't make much difference, but give it a try anyway. The important thing is to pick a time of day when you can take it consistently.
You seem very knowledgeable. I hope you have time to answer my question. I’m 10 days in on Anafranil. I’m shaking a lot and my anxiety has increased? Is this normal. I moved up to 150 mg 3 days ago.