As you know I have been suffering with anxiety and my doctor has now started me on 25mg of sertraline which I have been on for 5 days. I am taking it with breakfast. My problem is it seems to be okay in the morning but in the afternoon for about 4 hours I get terrible physical symptoms which include weakness, lethargy,shaking,racing heart. When the evening arrives I begin to feel better. On Monday she wants me to up the dose to 50mg but because of these symptoms I am a bit wary of doing so. Has anyone else had similar symptoms when starting on this drug.